A2
Prof. Dr. Bremmer

Predictive encoding of self-motion information in the primate brain

Planned research

The perception of self-motion is a central task in everyday life. Surprisingly, predictive aspects and multisensory consequences of self-motion (beyond vision and vestibular signals) are barely considered and, hence, are at the core of this project. In our studies, we will combine behavioral, EEG and functional imaging studies in humans with neurophysiological recordings and EEG in the animal model, i.e. the rhesus macaque. In monkey cell recordings, we will functionally characterize anticipatory and multisensory self-motion responses. In a cross-species approach we will investigate, if self-motion information in primates is processed pre-attentively. Finally, in a functional imaging study in humans we will study the multisensory integration of visual, auditory and tactile self-motion information. Overall, we expect from this combined approach a much better understanding of predictive aspects and multisensory consequences of self-motion processing in primates. 

Current research

Goal directed self-motion is a central behavioral task in everyday life. Despite its importance, the neural basis of the encoding of self-motion is far from being understood. This project centers around the question how predictable sensory signals as induced by self-motion are processed in the primate brain and how different sensory signals (visual, auditory and tactile) interact during self-motion. We will combine behavioral and functional imaging studies in humans with neurophysiological recordings in the animal model, i.e. the rhesus macaque. In the long term we expect a better understanding of the effects of prediction on the neural processing of the sensory consequences of action. 

new project-related publications
Churan, J., von Hopffgarten, A., & Bremmer, F. (2018). Eye movements during path integration. Physiological reports, 6(22), e13921. find paper DOI
Engel, D., Schütz, A., Krala, M., Schwenk, J. C. B., Morris, A. P., Bremmer, F. (2020). Inter-trial phase coherence of visually evoked postural responses in virtual reality. Experimental brain research, 238(5), 1177-1189. find paper DOI
Krala, M., van Kemenade, B., Straube, B., Kircher, T., & Bremmer, F. (2019). Predictive coding in a multisensory path integration task: An fMRI study. Journal of Vision, 19(11), 13-13. find paper
Schmitt, C., Baltaretu, B. R., Crawford, J. D., & Bremmer, F. (2020). A Causal Role of Area hMST for Self-Motion Perception in Humans. Cerebral Cortex Communications, 1(1), tgaa042. find paper
Schmitt, C., Klingenhoefer, S., & Bremmer, F. (2018). Preattentive and Predictive Processing of Visual Motion. Scientific reports, 8(1), 12399. find paper DOI
former project-related publications
Bremmer F, Churan J, Lappe M (2017). Heading representations in primates are compressed by saccades. Nature Communications, 8(1), 920. DOI find paper
Bremmer F., Duhamel J.-R., Ben Hamed S., & Graf W. (2002). Heading encoding in the macaque ventral intraparietal area (VIP). European Journal of Neuroscience 16, 1554-1568.
Bremmer, F., Churan, J., & Lappe, M. (2017). Heading representations in primates are compressed by saccades. Nature Communications, 8(1), 920. find paper DOI
Bremmer, F., Kubischik, M., Hoffmann, K.-P., & Krekelberg, B. (2009). Neural dynamics of saccadic suppression. Journal of Neuroscience, 29(40), 12374-12383.
Bremmer, F., Kubischik, M., Pekel, M., Hoffmann, K.P., & Lappe, M. (2010). Visual selectivity for heading in monkey area MST. Exp. Brain Res. 200, 51-60.
Bremmer, F., Schlack, A., Kaminiarz, A., & Hoffmann, K.P. (2013). Encoding of movement in near extrapersonal space in primate area VIP. Front Behav Neurosci 7:8. doi: 10.3389/fnbeh.2013.00008.
Bremmer, F., Schlack, A., Shah, N.J., Zafiris, O., Kubischik, M., Hoffmann, K.-P., Zilles, K. & Fink, G.R. (2001). Polymodal motion processing in posterior parietal and premotor cortex: a human fMRI study strongly implies equivalencies between humans and monkeys. Neuron, 29, 287-296.
Churan J , Paul J, Klingenhoefer S, Bremmer F (2017). Integration of visual and tactile information in reproduction of traveled distance. J Neurophysiology, in press. DOI find paper
Dowiasch, S., Backasch, B., Einhauser, W., Leube, D., Kircher, T., & Bremmer, F. (2016). Eye movements of patients with schizophrenia in a natural environment. European archives of psychiatry and clinical neuroscience, 266, 43-54. find paper
Dowiasch, S., Marx, S., Einhäuser, W., & Bremmer, F. (2015). Effects of aging on eye movements in the real world. Frontiers in Human Neuroscience. 9:46.DOI find paper
Hesse P.N., Schmitt C., Klingenhoefer S. Bremmer F. (2017). Preattentive Processing of Numerical Visual Information. Frontiers in Human Neuroscience, 11:70. DOI find paper
Kaminiarz A., Schlack A., Hoffmann K.P., Lappe M., Bremmer F. (2014). Visual selectivity for heading in the macaque ventral intraparietal area. Journal of Neurophysiology, 112 (10), 2470-80. find paper
Krekelberg, B., Dannenberg, S., Hoffmann, K.-P., Bremmer, F. & Ross, J. (2003). Neural correlates of implied motion. Nature, 424, 674-677.
Lich, M. & Bremmer, F. (2014). Self-Motion Perception in the Elderly. Front Hum Neurosci., 8:681.DOI find paper
M.W. Greenlee, S.M. Frank, M. Kaliuzhna, O. Blanke, F. Bremmer, J. Churan, L.F. Cuturi, P.R. MacNeilage, & A.T. Smith (2016). Multisensory integration in self motion perception. Multisensory Research. 29(6-7), 525-556. find paper
Schlack, A., Sterbing-D'Angelo, S.J., Hartung, K., Hoffmann, K.-P. & Bremmer, F. (2005). Multisensory space representations in the macaque ventral intraparietal area (VIP). Journal of Neuroscience, 25, 4616 – 4625.
von Hopffgarten, A., & Bremmer, F. (2011). Self-motion reproduction can be affected by associated auditory cues. Seeing & Perceiving 24, 203-222.