B7
Prof. Dr. Mulert

Neurochemical and neurophysiological mechanisms in the interaction of reward processing with bottom-up and top down networks: The role of dopamine and E/I balance

Project B7 investigates the interaction of bottom-up and top-down visual attention with reward processes in healthy subjects and patients with schizophrenia. The main focus of project B7 lies on the neurophysiological and neurochemical mechanisms of this interaction. We will use neuropharmacological modulation at the dopamine receptor together with trial-by-trial coupling of simultaneous EEG-fMRI, multichannel-tACS and advanced electrical field modeling to probe the causal role of neural oscillations in this process and MR-Spectroscopy to characterize the relationship of glutamate concentrations in the visual cortex and the ACC with visual selection.

new project-related publications
Andreou, C., Steinmann, S., Kolbeck, K., Rauh, J., Leicht, G., Moritz, S., Mulert, C. (2018). The role of effective connectivity between the task-positive and task-negative network for evidence gathering [Evidence gathering and connectivity]. Neuroimage, 173, 49-56. find paper
Curic, S., Leicht, G., Thiebes S., Andreou C., Polomac, N., Eichler, I.C., Eichler, L., Zöllner, C., Gallinat, J., Steinmann, S., Mulert, C. (2019). Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine. Neuropsychopharmacology, 44(7), 1239-1246. find paper
Elyamany, O., Leicht, G., Herrmann, C. S., & Mulert, C. (2020). Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry. European Archives of Psychiatry and Clinical Neuroscience, 1-22. find paper
Haaf, M., Curic, S., Steinmann, S., Rauh, J., Leicht, G., & Mulert, C. (2021). Glycine attenuates impairments of stimulus-evoked gamma oscillation in the ketamine model of schizophrenia. bioRxiv. find preprint
Kornmayer, L., Leicht, G. and Mulert, C. (2018). Attentional capture by physically salient stimuli in the gamma frequency is associated with schizophrenia symptoms. The World Journal of Biological Psychiatry, 19(sup2), S52-S62. find paper
Leicht, G., Andreou, C., Nafe, T., Nägele, F., Rauh, J., Curic, S., Schauer, P., Schöttle, D., Steinmann, S., Mulert, C. (2020). Alterations of oscillatory neuronal activity during reward processing in schizophrenia. Journal of Psychiatric Research, 129, 80-87. find paper
Lockhofen, D. E. L., Hübner, N., Hemdan, F., Sammer, G., Henare, D., Schubö, A., & Mulert, C (2021). Differing Time Courses of Reward-Related Attentional Processing: An EEG Source-Space Analysis. Brain Topography, 34(3), 283-296. find paper
Meier, J., Nolte, G., Schneider, T.R., Engel, A.K., Leicht, G., Mulert C. (2019). Intrinsic 40Hz-phase asymmetries predict tACS effects during conscious auditory perception. Plos One, 14(4), e0213996. find paper
Thiebes, S., Steinmann, S., Curic, S., Polomac, N., Andreou, C., Eichler, I.C., Eichler, L., Zöllner, C., Gallinat J., Leicht, G., Mulert, C. (2018). Alterations in interhemispheric gamma-band connectivity are related to the emergence of auditory verbal hallucinations in healthy subjects during NMDA-receptor blockade. Neuropsychopharmacology, 43(7), 1608-1615. find paper
former project-related publications
Andreou, C., Frielinghaus, H., Rauh, J., Mußmann, M., S. Vauth, S., Braun, P., Leicht, G. and Mulert, C. (2017). Theta and high-beta networks for feedback processing: a simultaneous EEG & fMRI study in healthy male subjects. Translational Psychiatry, 7(1), e1016. find paper
Kornmayer, L., Leicht, C. and Mulert, C. (2015). Increased gamma oscillations evoked by physically salient distracters are associated with schizotypy. Brain Topography, 28(1), 153-161. find paper
Leicht, G., Vauth, S. Polomac, N., C. Andreou, C., Rauh, J., Mussmann, M., Karow, A., and Mulert, C. (2016). EEG-Informed fMRI Reveals a Disturbed Gamma-Band-Specific Network in Subjects at High Risk for Psychosis. Schizophrenia Bulletin, 42(1), 239-249. find paper