A3
Prof. Dr. Kircher und Prof. Dr. Straube

Prädiktive Wahrnehmungsprozesse: multisensorische Konsequenzen eigener Handlungen

Projekt A3 kombiniert Psychophysik, EEG und fMRT, um handlungsbezogene multisensorische Vorher- sagesprozesse besser zu verstehen. Wir werden kontextuelle Einflüsse und individuelle Unterschiede im Handlungs-Wahrnehmungs-Schaltkreis untersuchen; insbesondere ob aus der Analyse einzelner Handbewegungen abgleitete Mechanismen sich übertragen lassen auf (1) Handlungssequenzen, (2) Fußbewegungen und (3) natürliche Kontexte (z.B. Radfahren). Mit EEG und kombinierter EEG-fMRT werden wir den (4) Zeitverlauf der prädiktiven neuronalen Verarbeitung und (5) individuelle Unterschiede in Personen mit schizotypen Persönlichkeitszügen beleuchten. Und ob (6) gestörte multisensorische Vorhersagen zu einer Beeinträchtigung der Handlungswahrnehmung bei Patienten mit Schizophrenie führen. Unsere Forschung überträgt grundlagenwissenschaftliche Erkenntnisse in den klinischen Kontext um Mechanismen aufzudecken, die Beeinträchtigungen der Handlungsüberwachung unter natürlichen Bedingungen zugrunde liegen.

Neue Projektrelevante Veröffentlichungen
Acosta, H., Straube, B., & Kircher, T. (2019). Schizotypy and mentalizing: An fMRI study. Neuropsychologia, 124, 299-310. find paper
Arikan, B. E., van Kemenade, B. M., Podranski, K., Steinsträter, O., Straube, B., & Kircher, T. (2019). Perceiving your hand moving: BOLD suppression in sensory cortices and the role of the cerebellum in the detection of feedback delays. Journal of Vision. find paper
Bitsch, F., Berger, P., Nagels, A., Falkenberg, I., & Straube, B. (2019). Impaired right temporoparietal junction–hippocampus connectivity in schizophrenia and its relevance for generating representations of other minds. Schizophrenia bulletin, 45(4), 934-945. find paper
Bitsch, F., Berger, P., Nagels, A., Falkenberg, I., & Straube, B. (2021). Characterizing the theory of mind network in schizophrenia reveals a sparser network structure. Schizophrenia Research, 228, 581-589. find paper
Choudhury, M., Steines, M., Nagels, A., Riedl, L., Kircher, T., & Straube, B. (2021). Neural Basis of Speech-Gesture Mismatch Detection in Schizophrenia Spectrum Disorders. Schizophrenia Bulletin. find paper
Cuevas, P., He, Y., Billino, J., Kozasa E. & Straube, B. (2021). Age-related effects on the neural processing of semantic complexity in a continuous narrative: Modulation by gestures already present in young to middle-aged adults. Neuropsychologia, 151:107725. find paper DOI
Cuevas, P., Steines, M., He, Y., Nagels, A., Culham, J., & Straube, B. (2019). The facilitative effect of gestures on the neural processing of semantic complexity in a continuous narrative. NeuroImage, 195, 38-47. find paper
He, Y., Luell, S., Muralikrishnan, R., Straube, B., & Nagels, A. (2020). Gesture's body orientation modulates the N400 for visual sentences primed by gestures. Human brain mapping, 41(17), 4901-4911. find paper
He, Y., Nagels, A., Schlesewsky, M., & Straube, B. (2018). The role of gamma oscillations during integration of metaphoric gestures and abstract speech. Frontiers in psychology, 9, 1348. find paper
He, Y., Steines, M., Sammer, G., Nagels, A., Kircher, T., & Straube, B. (2018). Action-related speech modulates beta oscillations during observation of tool-use gestures. Brain topography, 31(5), 838-847. find paper
He, Y., Steines, M., Sammer, G., Nagels, A., Kircher, T., & Straube, B. (2021). Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia. NeuroImage: Clinical, 29, 102568. find paper DOI
He, Y., Steines, M., Sommer, J., Gebhardt, H., Nagels, A., Sammer, G., Kircher, T., Straube, B. (2018). Spatial - temporal dynamics of gesture - speech integration: a simultaneous EEG-fMRI study. Brain Structure and Function, 223(7), 3073-3089. find paper DOI
Krala, M., van Kemenade, B., Straube, B., Kircher, T., & Bremmer, F. (2019). Predictive coding in a multisensory path integration task: An fMRI study. Journal of Vision, 19(11), 13-13. find paper DOI
Nagels, A., Kircher, T., Grosvald, M., Steines, M., & Straube, B. (2019). Evidence for gesture-speech mismatch detection impairments in schizophrenia. Psychiatry research, 273, 15-21. find paper
Pazen, M., Uhlmann, L., van Kemenade, B. M., Steinsträter, O., Straube, B., & Kircher, T. (2020). Predictive perception of self-generated movements: Commonalities and differences in the neural processing of tool and hand actions. NeuroImage, 206, 116309. find paper DOI
Riedl, L., Nagels, A., Sammer, G., & Straube, B. (2020). A multimodal speech-gesture training intervention for patients with schizophrenia and its neural underpinnings–the study protocol of a randomized controlled pilot trial. Frontiers in psychiatry, 11, 110. find paper
Schmitter, C., Steinsträter, O., Kircher, T., van Kemenade, B. M., & Straube, B. (2021). Commonalities and differences in predictive neural processing of discrete vs continuous action feedback. NeuroImage, 229, 117745. find paper DOI
Schülke, R., & Straube, B. (2019). Transcranial direct current stimulation improves semantic speech–gesture matching in patients with schizophrenia spectrum disorder. Schizophrenia bulletin, 45(3), 522-530. find paper
Steines, M., Nagels, A., Kircher, T., & Straube, B. 2 (2021). The role of the left and right inferior frontal gyrus in processing metaphoric and unrelated co-speech gestures. NeuroImage, 237, 118182. find paper
Straube, B., van Kemenade, B.M., Kircher, T. & Schülke, R. (2020). Transcranial Direct Current Stimulation Improves Action-Outcome Monitoring in Schizophrenia Spectrum Disorder. Brain Communications, 2(2), fcaa151. find paper DOI
Uhlmann, L., Pazen, M., van Kemenade, B. M., Steisträter, O., Harris, L.R., Kircher, T. & Straube, B (2020). Seeing your own or someone else's hand moving in accordance with your action: The neural interaction of agency and hand identity. Human Brain Mapping, 41, 2474-2489. find paper DOI
Uhlmann, L., Pazen, M., van Kemenade, B.M., Kircher, T. & Straube, B. (2021). Neural correlates of self-other distinction in patients with schizophrenia spectrum disorders: The roles of agency and hand identity. Schizophrenia Bulletin. find paper DOI
Van Kemenade, B.M., Arikan, B.E., Podranski, K., Steinsträter, O., Kircher, T., & Straube, B. (2019). Distinct roles for the cerebellum, angular gyrus and middle temporal gyrus in action-feedback monitoring. Cerebral Cortex. find paper DOI
Wroblewski, A., He, Y., & Straube, B. (2020). Dynamic Causal Modelling suggests impaired effective connectivity in patients with schizophrenia spectrum disorders during gesture-speech integration. Schizophrenia research, 216, 175-183. find paper
Ältere projektrelevante Veröffentlichungen
Arikan , B.E., van Kemenade , B.M., Straube, B., Harris, L.H., & Kircher , T. (2017). Voluntary and Involuntary Movements Widen the Window of Subjective Simultaneity. i-Perception, 8(4), 2041669517719297. find paper DOI
Backasch, B., Sommer, J., Klöhn-Saghatolislam, F., Müller, M.J., Kircher, T.T., & Leube, D.T. (2014). Dysconnectivity of the inferior frontal gyrus: Implications for an impaired self-other distinction in patients with schizophrenia. Psychiatry Research, 223:202-209. find paper
Blos, J., Chatterjee, A., Kircher, T., & Straube, B. (2012). Neural correlates of causality judgment in physical and social context – the reversed effects of space and time. NeuroImage, 63(2), 882-93.
Green, A., Straube, B., Weis, S., Jansen, A., Willmes, K., Konrad, K., & Kircher, T. (2009). Neural integration of iconic and unrelated coverbal gestures: a functional MRI study. Human Brain Mapping, 30(10), 3309–3324.
He, Y., Gebhardt, H., Steines, M., Sammer, G., Kircher, T., Nagels, A., & Straube, B. (2015). The EEG and fMRI signatures of neural integration: An investigation of meaningful gestures and corresponding speech. Neuropsychologia, 72, 27-42.DOI find paper
Knoblich G., Stottmeister F., Kircher T. (2004). Self-monitoring in patients with schizophrenia. Psychol Med., 34, 1561-9.
Knoblich, G., & Kircher, T. (2004). Deceiving Oneself About Being in Control: Conscious Detection of Changes in Visuomotor Coupling. Journal of Experimental Psychology: Human Perception and Performance, 30(4), 657–666.
Leube D.T., Knoblich G., Erb M., Grodd W., Bartels M., Kircher T.T. (2003b). The neural correlates of perceiving one's own movements. Neuroimage, 20, 2084- 90.
Leube D.T., Knoblich G., Erb M., Kircher T.T. (2003a). Observing one's hand become anarchic: an fMRI study of action identification. Conscious Cogn, 12, 597-608.
Leube DT, Knoblich G, Erb M, Schlotterbeck P, Kircher T (2010). The neural basis of disturbed efference copy mechanism in patients with schizophrenia. Cognitive Neuroscience, 1, 111-117.
Lindner A., Thier P., Kircher T.T., Haarmeier T., Leube D.T. (2005). Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions. Curr Biol., 15, 1119-24.
Mainieri A.G., Heim S., Straube B., Binkofski F., Kircher T. (2013). Differential Role of Mentalizing and the Mirror Neuron System in the Imitation of Communicative Gestures. NeuroImage, 81, 294–305.
Nagels, A., Kircher, T., Steines, M., Grosvald, M., & Straube, B. (2015). A brief self-rating scale for the assessment of individual differences in gesture perception and production. Learning and Individual Differences, 39, 73–80. DOI find paper
Schmalenbach, S.B., Billino, J., Kircher, T., van Kemenade, B.M., & Straube, B. (2017). Links between gestures and multisensory processing: individual differences suggest a compensation mechanism. Frontiers in Psychology, 8:1828 find paper DOI
Schuelke, R., & Straube, B. (2017). Modulating the assessment of semantic speech–gesture relatedness via transcranial direct current stimulation of the left frontal cortex. Brain Stimulation, 10(2), 223–230. DOI find paper
Straube B., Wolk D., Chatterjee A. (2011). The role of the right parietal lobe in the perception of causality: a tDCS study. Experimental Brain Research, 215(3), 315–325.
Straube, B., Green, A., Bromberger, B. & Kircher, T. (2011). The differentiation of iconic and metaphoric gestures: Common and unique integration processes. Human Brain Mapping, 32, 520-533.
Straube, B., Green, A., Sass, K., & Kircher, T. (2014). Superior Temporal Sulcus Disconnectivity During Processing of Metaphoric Gestures in Schizophrenia. Schizophrenia Bulletin, 40(4), 936?944. DOI find paper
Straube, B., Green, A., Weis, S., & Kircher, T. (2012). A Supramodal Neural Network for Speech and Gesture Semantics: An fMRI Study. PLoS ONE, 7(11), e51207. doi:10.1371/journal.pone.0051207.
Straube, B., He, Y., Steines, M., Gebhardt, H., Kircher, T., Sammer, G., & Nagels, A. (2013). Supramodal neural processing of abstract information conveyed by speech and gesture. Frontiers in Behavioral Neuroscience, 7. doi:10.3389/fnbeh.2013.00120
Straube, B., van Kemenade, B. M., Arikan, B. E., Fiehler, K., Harris, L. R., Leube, D., & Kircher, T. (2017). Predicting the multisensory consequences of one's own action: BOLD suppression in auditory and visual cortices. PLOS ONE, 12(1), e0169131. DOI find paper
Van Kemenade, B. M., Kircher, T., Arikan, B. E., & Straube, B. (2016). Predicting the sensory consequences of one’s own action: First evidence for multisensory facilitation. Attention, Perception, & Psychophysics, 78(8), 2515-2526. DOI find paper
van Kemenade, B.M., Arikan, B.E., Kircher, T., & Straube, B. (2017). The angular gyrus is a supramodal comparator area in action-outcome monitoring. Brain Structure and Function, 1-13. DOI find paper
Wende, K. C., Nagels, A., Stratmann, M., Chatterjee, A., Kircher, T., & Straube, B. (2015). Neural basis of altered physical and social causality judgements in schizophrenia. Schizophrenia Research, 161(2–3), 244–251. find paper